Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors

BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS Abstract 0 p Imr R Q A-W1 The invention provides novel compounds having the general formula (I) wherein R', R2, A, W, m, n, p and q are as described herein, compositions including the compounds. The comp...

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Bibliographic Details
Main Authors KUEHNE, Holger, HERT, Jerome, RUDOLPH, Markus, DI GIORGIO, Patrick, MATTEI, Patrizio, HUNZIKER, Daniel
Format Patent
LanguageEnglish
Published 27.05.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS Abstract 0 p Imr R Q A-W1 The invention provides novel compounds having the general formula (I) wherein R', R2, A, W, m, n, p and q are as described herein, compositions including the compounds. The compounds of formula (I) are useful as autotaxin (ATX) inhibitors which are inhibitors of lysophosphatidic acid (LPA) production and thus modulators of LPA levels and associated signalling; in particular they are useful for the treatment or prophylaxis of renal conditions, liver conditions, inflammatory conditions, conditions of the nervous system, conditions of the respiratory system, vascular and cardiovascular conditions, fibrotic diseases, cancer, ocular conditions, metabolic conditions, cholestatic and other forms of chronic pruritus and acute and chronic organ transplant rejection.
Bibliography:Application Number: AU20190257457