Methods and compositions for treating skin disease with recombinant microorganisms

The present disclosure provides methods and compositions for treating skin diseases, comprising an engineered microorganism expressing therapeutically relevant recombinant fusion polypeptides. In one embodiment, the disclosure provides a method for treating skin disease, such as atopic dermatitis, c...

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Bibliographic Details
Main Author WHITFILL, Travis Michael
Format Patent
LanguageEnglish
Published 22.10.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides methods and compositions for treating skin diseases, comprising an engineered microorganism expressing therapeutically relevant recombinant fusion polypeptides. In one embodiment, the disclosure provides a method for treating skin disease, such as atopic dermatitis, comprising administering a to a subject in need thereof a composition comprising live biotherapeutic product (LBP) comprising human filaggrin-secreting Staphylococcus epidermidis. In a further aspect, the present invention provides a pharmaceutical composition comprising a filaggrin polypeptide described herein. Further still, the present invention provides a kit comprising a composition disclosed herein and instructions for use.
Bibliography:Application Number: AU20190249249