CD3-negative cell population expressing chemokine receptor and cell adhesion molecule, use thereof, and method for producing same

• Main Authors: YONEMITSU, Yoshikazu, HARADA, Yui
• Format: Patent
• Language: English
• Published: 19.11.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention pertains to immune cells having higher cytotoxic activity, and a pharmaceutical composition for performing highly effective NK cell therapy. The present invention provides a cell population containing cells that are CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative. The present invention provides a cell population in which cells that are CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative furthermore express a high level of CD11c. The present invention provides cells that invade solid tumors and are CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative. The present invention also provides a pharmaceutical composition containing such a cell population and a pharmacologically acceptable additive. Furthermore, the present invention provides a method for producing the cell population.