Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

• Main Authors: BRYS, Reginald Christophe Xavier, JONCOUR, Agnes, BOCK, Xavier, DESROY, Nicolas, HECKMANN, Bertrand, PEIXOTO, Christophe
• Format: Patent
• Language: English
• Published: 18.07.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

:\dar\nterwovn\NRPortbl\DCC\DAR\16210528_l.docx-20/12/2017 The present invention discloses compounds according to Formula I: Wherein Ria, R, R2, R4 , 5 6a 6b 7 8 R , Ra, Rob, R , R', W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention. Rla Rlb (R 7 )a R" \ R2 R8 Cy N .W R6b N