Injectable controlled release composition comprising high viscosity liquid carrier

• Main Authors: TAMRAZ, Wilma, GIBSON, John W, LEONARD, John J, SJOBECK, Stefania, BRANHAM, Keith E, BOYD, Brooks, RUBINO, Christopher M, WRIGHT, Jeremy C
• Format: Patent
• Language: English
• Published: 16.07.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A carrier formulation for controlled release of injectable drugs is disclosed. The formulation comprises a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM) like sucrose acetate isobutyrate, a lactic acid-based polymer like poly(lactic acid) (glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25°C in one atmosphere. The drug is released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti- schizophrenia agent delivered by injection. WO 2014/164754 PCT/US2014/023397 35"._ - _ _ _ _ _ _ _ _ _ _ _ _ _ _ -- o100 mg Risperidone E30 - - --- -)-..---_ _--- .4-50Omg Risperidone-. -4#-25mg Risperidone c25 ... _.. 0 -'---"--r--r---r---"---F--T*--r I" 0 7 14 21 28 35 Time (days)