Solid forms of an ASK1 inhibitor

Crystalline forms of 5-(4-cyclopropyl-lH-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3 yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms. N " N...

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Main Authors Andres, Mark, Chan, Brenda J. Burke, Lathrop, Stephen P, Carra, Ernest A, Notte, Gregory, Lapina, Olga Viktorovna, Smolenskaya, Valeriya, Yu, Lok Him, Chiu, Anna
Format Patent
LanguageEnglish
Published 07.02.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Crystalline forms of 5-(4-cyclopropyl-lH-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3 yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms. N " N N N , N C H m pN Compound I
Bibliography:Application Number: AU20190200333