Cross-linked pyrrolobenzodiazepine dimer (PBD) derivative and its conjugates

A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.

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Bibliographic Details
Main Authors ZHAO, Robert Yongxin, LI, Wenjun, ZHUO, Xiaotao, GAI, Shun, GUO, Zhixiang, ZHENG, Jun, HUANG, Yuanyuan, YE, Zhichang, YANG, Yanlei, JIA, Junxiang, YANG, Qingliang, ZHOU, Xiaomai, GUO, Huihui, LEI, Jun, YANG, Chengyu, ZHAO, Linyao, XIE, Hongsheng, YE, Hangbo, BAI, Lu, CAO, Mingjun
Format Patent
LanguageEnglish
Published 18.02.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.
Bibliography:Application Number: AU20180430758