Rapamycin analogs as mTOR inhibitors

The present disclosure relates to rapamycin analogs of the general Formula (I). The compounds are inhibitors of mTOR and thus useful for the treatment of cancer, immune-mediated diseases and age related conditions.

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Bibliographic Details
Main Authors Pitzen, Jennifer, Gliedt, Micah James Evans, Wang, Gang, Lee, Julie Chu-Li, Semko, Christopher, Burnett, G. Leslie, Kiss, Gert, Aggen, James Bradley, Gill, Adrian Liam, Thottumkara, Arun P, Tibrewal, Nidhi, Won, Walter
Format Patent
LanguageEnglish
Published 28.11.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to rapamycin analogs of the general Formula (I). The compounds are inhibitors of mTOR and thus useful for the treatment of cancer, immune-mediated diseases and age related conditions.
Bibliography:Application Number: AU20180263886