Activation of bioluminescence by structural complementation

Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non 5 luminescent polypeptide via structural c...

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Main Authors WOOD, Monika, DIXON, Andrew S, SCHWINN, Marie, NATH, Nidhi, DART, Melanie, KIRKLAND, Thomas, WOOD, Keith, ZEGZOUTI, Hicham, ROBERS, Matthew, UNCH, James, MEISENHEIMER, Poncho, MACHLEIDT, Thomas, HALL, Mary, GOUELI, Said, PULUKKUNAT, Dileep K, MONDAL, Subhanjan, BINKOWSKI, Brock F, ENCELL, Lance
Format Patent
LanguageEnglish
Published 14.05.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non 5 luminescent polypeptide via structural complementation with another, complementary non luminescent peptide. 10721702_1 (GHMatters) P100944.AU.1
Bibliography:Application Number: AU20180256548