Bicyclic compounds as allosteric SHP2 inhibitors

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

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Bibliographic Details
Main Authors Koltun, Elena S, Gill, Adrian, Semko, Christopher, Tzitzilonis, Christos, Kiss, Gert, Won, Walter S, Aay, Naing, Li, Jie Jack, Jogalekar, Ash, Pitzen, Jennifer, Blank, Brian R, Wang, Gang, Mellem, Kevin, Buckl, Andreas
Format Patent
LanguageEnglish
Published 15.08.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
Bibliography:Application Number: AU20180210770