STORAGE STABLE ZINC ERYTHROMYCIN CONTAINING LOW DIELECTRIC SOLVENTS

A storage stable topical pharmaceutical composition containing zinc erythromycin, particularly useful in the topical treatment of acne vulgaris, is disclosed. This composition contains a solvent having a dielectric constant, measured at 25°C, of from about 5.5 to about 15, preferably from about 8 to...

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Bibliographic Details
Main Authors WILLIAM JOSEPH KOZAREK, JAMES EDSON HUGGINS, MARY LOUISE BATT
Format Patent
LanguageEnglish
Published 19.04.1984
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Summary:A storage stable topical pharmaceutical composition containing zinc erythromycin, particularly useful in the topical treatment of acne vulgaris, is disclosed. This composition contains a solvent having a dielectric constant, measured at 25°C, of from about 5.5 to about 15, preferably from about 8 to about 12. such as t-butanol, to impart storage stability to the zinc erythromycin component. The composition may additonally contain particularly selected pharmaceutically-acceptable ni- trogencontaining stabilizer components, such as diisopropanolamine.
Bibliography:Application Number: AU19830020174