Reagents for producing T-cells with non-functional T-cell receptors (TCRs) compositions comprising same and use thereof

The present disclosure relates to reagents for producing T-cells comprising non- functional T-cell receptors (TCR), including T-cells which also express chimeric antigen receptors (CAR), i.e., CAR-T cells, compositions comprising said reagents and T-cells, and uses of said CAR-T cells in therapy e.g...

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Bibliographic Details
Main Authors Suhy, David, Strings-Ufombah, Vanessa, Graham, Michael, Roelvink, Peter, Garcia, Patty Bertha
Format Patent
LanguageEnglish
Published 11.04.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present disclosure relates to reagents for producing T-cells comprising non- functional T-cell receptors (TCR), including T-cells which also express chimeric antigen receptors (CAR), i.e., CAR-T cells, compositions comprising said reagents and T-cells, and uses of said CAR-T cells in therapy e.g., adoptive therapy.
Bibliography:Application Number: AU20170326748