4,6-diaminoquinazolines as Cot modulators and methods of use thereof

• Main Authors: Kim, Musong, Balan, Gayatri, Kirschberg, Thorsten A, Saito, Roland D, Squires, Neil H, Link, John O, Chou, Chien-Hung, Phillips, Gary, Taylor, James G, Watkins, William J, Wright, Nathan E
• Format: Patent
• Language: English
• Published: 23.07.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to 4,6-diaminoquinazoline derivatives of formula I which are modulators of the Cot (cancer Osaka thyroid) kinase, also known as MAP3K8, EST or Tlp-2, and their use for treating e.g. cancer, diabetes and inflammatory diseases.