4,6-diaminoquinazolines as Cot modulators and methods of use thereof

The invention relates to 4,6-diaminoquinazoline derivatives of formula I which are modulators of the Cot (cancer Osaka thyroid) kinase, also known as MAP3K8, EST or Tlp-2, and their use for treating e.g. cancer, diabetes and inflammatory diseases.

Saved in:
Bibliographic Details
Main Authors Kim, Musong, Balan, Gayatri, Kirschberg, Thorsten A, Saito, Roland D, Squires, Neil H, Link, John O, Chou, Chien-Hung, Phillips, Gary, Taylor, James G, Watkins, William J, Wright, Nathan E
Format Patent
LanguageEnglish
Published 23.07.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention relates to 4,6-diaminoquinazoline derivatives of formula I which are modulators of the Cot (cancer Osaka thyroid) kinase, also known as MAP3K8, EST or Tlp-2, and their use for treating e.g. cancer, diabetes and inflammatory diseases.
Bibliography:Application Number: AU20170289158