Novel pyrazole derivative as ALK5 inhibitor and uses thereof
The present invention relates to a novel substituted pyrazole derivative, having the effect of inhibiting the serine/threonine kinase activity, targeting the receptor ALK5 of TGF-β. A pharmaceutical composition containing a compound of the present invention as an active ingredient can be usefully us...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
25.06.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to a novel substituted pyrazole derivative, having the effect of inhibiting the serine/threonine kinase activity, targeting the receptor ALK5 of TGF-β. A pharmaceutical composition containing a compound of the present invention as an active ingredient can be usefully used in the treatment and/or prevention of cancer, an autoimmune disease, a fibrotic disease, an inflammatory disease, a neurodegenerative disease, an infectious disease, a pulmonary disease, a cardiovascular disease or a metabolic disease or other diseases associated with a decrease in TGF family signaling activity. |
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Bibliography: | Application Number: AU20170289021 |