Inhibitors of beta-secretase

1: \dar\Interwoven\NRPortbl\DCC\DAR\15766525_l.docx-28 09/2017 Abstract The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the p-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic ag...

Full description

Saved in:
Bibliographic Details
Main Authors BUKHTIYAROV, Yuri, LALA, Deepak S, CACATIAN, Salvacion, XU, Zhenrong, REEVES, Jonathan, ZHENG, Yajun, DILLARD, Lawrence Wayne, ZHAO, Yi, SINGH, Suresh B, MORALES-RAMOS, Angel, JIA, Lanqi, VENKATRAMAN, Shankar, DORNER-CIOSSEK, Cornelia, RAST, Georg, YUAN, Jing, FUCHS, Klaus
Format Patent
LanguageEnglish
Published 03.01.2019
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:1: \dar\Interwoven\NRPortbl\DCC\DAR\15766525_l.docx-28 09/2017 Abstract The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the p-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of p-amyloid aggregates.
Bibliography:Application Number: AU20170236042