Purified cardiogenin isomer and related methods

PURIFIED CARDIOGENIN ISOMER AND RELATED METHODS A cardiogenin major isomer is obtained from a methanol extract of Geumjaponicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak@ ICTm column. The purity of t...

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Main Authors FREUND, Ernst, KYAS, Andreas, PATERNITI, James R, LILL, Jorg, MENIA, Dario, SCHLORKE, Oliver, ELLIOTT, Gary, ROGALL, Lars
Format Patent
LanguageEnglish
Published 02.03.2017
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
SUGARS
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Summary:PURIFIED CARDIOGENIN ISOMER AND RELATED METHODS A cardiogenin major isomer is obtained from a methanol extract of Geumjaponicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak@ ICTm column. The purity of the isolated cardiogenin major isomer can be further increased by crystallization, yielding isolated cardiogenin major isomer having HPLC purity as high as 98.97% (a/a) at 210 nm and a potency of 95.50%) (w/w). #12578490
Bibliography:Application Number: AU20170200924