Preparation of latanoprostene bunod of desired, pre-defined quality by gravity chromatography

The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silicagel column chromatography where the used silicagel is irregular silicagel or spherical silicagel an as e...

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Main Authors Lászlófi, István, Fekete, Ibolya, Havasi, Gábor, Takács, László, Buzder-Lantos, Péter, Hortobágyi, Irén, Kardos, Zsuzsanna
Format Patent
LanguageEnglish
Published 01.04.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silicagel column chromatography where the used silicagel is irregular silicagel or spherical silicagel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silicagel filtration chromatography.
Bibliography:Application Number: AU20160364014