Nucleic acid derivative having immunostimulatory activity

The purpose of the present invention is to provide a double-stranded oligonucleotide comprising the CpG oligonucleotides mentioned below, as a nucleic acid derivative having an immunostimulatory activity. An adjuvant comprising a double-stranded oligonucleotide, wherein a first strand is a CpG oligo...

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Bibliographic Details
Main Authors Kugimiya, Akira, Sekiguchi, Mitsuaki, Tanino, Tetsuya, Nakamura, Jun, Kuroda, Norikazu, Mitsuoka, Yasunori
Format Patent
LanguageEnglish
Published 07.05.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The purpose of the present invention is to provide a double-stranded oligonucleotide comprising the CpG oligonucleotides mentioned below, as a nucleic acid derivative having an immunostimulatory activity. An adjuvant comprising a double-stranded oligonucleotide, wherein a first strand is a CpG oligonucleotide which is composed of 8 to 50 nucleotides, a second strand is an oligonucleotide which is composed of 8 to 60 nucleotides and contains a sequence capable of hybridizing with the first strand, and a lipid is bonded to the second strand through a linker or without a linker.
Bibliography:Application Number: AU20160332266