Bispecific antibodies specific for PD1 and TIM3

The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity...

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Bibliographic Details
Main Authors Codarri-Deak, Laura, Wuensche, Ildiko, Seeber, Stefan, Lifke, Valeria, Perro, Mario, Fertig, Georg, Regula, Joerg Thomas, Levitski, Viktor, Fischer, Jens, Klein, Christian, Umaña, Pablo, Schlothauer, Tilman, Zwick, Adrian
Format Patent
LanguageEnglish
Published 13.04.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.
Bibliography:Application Number: AU20160329126