Sulfonamide compounds as voltage-gated sodium channel modulators

The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to...

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Main Authors Palle, Venkata P, Ramdas, Vidya, Loriya, Rajeshkumar Maganlal, Gote, Ganesh Navinchandra, Khan, Talha Hussain, Kalhapure, Vaibhav Madhukar, Kamboj, Rajender Kumar, Banerjee, Moloy, Joshi, Advait Arun, Walke, Deepak Sahebrao, Patil, Pradeep Rangrao, Datrange, Laxmikant Shamlal, Das, Amit Kumar
Format Patent
LanguageEnglish
Published 15.03.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention. (I)
Bibliography:Application Number: AU20160314355