Bispecific antibody constructs binding DLL3 and CD3

The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a Tcell. Moreover, the invention provides a polynucleotide encoding the...

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Bibliographic Details
Main Authors Bluemel, Claudia, Raum, Tobias, Kufer, Peter, Hoffmann, Patrick, Lutterbuese, Ralf, Pendzialek, Jochen, Dahlhoff, Christoph, Nahrwold, Elisabeth
Format Patent
LanguageEnglish
Published 25.08.2022
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a Tcell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
Bibliography:Application Number: AU20160302569