1' -substituted carba-nucleoside analogs for antiviral treatment

• Main Authors: Saunders, Oliver L, Parrish, Jay, Butler, Thomas, Zhang, Lijun, Cho, Aesop, Kim, Choung U
• Format: Patent
• Language: English
• Published: 09.08.2018
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

Provided are pyrrolo[ 1,2-fl [1,2,4]triazinyl, imidazo[ 1,5-fl [1,2,4]triazinyl, imidazo[ 1,2 f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the I 'position of the nucleoside sugar is substituted. The 5 compounds,...