1' -substituted carba-nucleoside analogs for antiviral treatment

Provided are pyrrolo[ 1,2-fl [1,2,4]triazinyl, imidazo[ 1,5-fl [1,2,4]triazinyl, imidazo[ 1,2 f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the I 'position of the nucleoside sugar is substituted. The 5 compounds,...

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Bibliographic Details
Main Authors Saunders, Oliver L, Parrish, Jay, Butler, Thomas, Zhang, Lijun, Cho, Aesop, Kim, Choung U
Format Patent
LanguageEnglish
Published 09.08.2018
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Provided are pyrrolo[ 1,2-fl [1,2,4]triazinyl, imidazo[ 1,5-fl [1,2,4]triazinyl, imidazo[ 1,2 f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the I 'position of the nucleoside sugar is substituted. The 5 compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. Formula (I), each X or X2 is independently C-R 10or N. Fonnula I
Bibliography:Application Number: AU20160250419