High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury

Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor 5 disease. In certain embodiments, the methods invo...

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Main Authors DESAUTELS, THOMAS ANTHONY, HODES, JONATHAN, ANGELI, CLAUDIA A, HARKEMA, SUSAN J, BURDICK, JOEL, ROY, ROLAND R, GERASIMENKO, YURY, TAI, YUONG, EDGERTON, VICTOR REGGIE, NANDRA, MANDHEEREJ S
Format Patent
LanguageEnglish
Published 08.09.2016
Subjects
ARTIFICIAL RESPIRATION
BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSESOR SPECIFIC PARTS OF THE BODY
ELECTROTHERAPY
HUMAN NECESSITIES
HYGIENE
MAGNETOTHERAPY
MASSAGE
MEDICAL OR VETERINARY SCIENCE
PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING ORSTIMULATING REFLEX POINTS IN THE BODY
RADIATION THERAPY
ULTRASOUND THERAPY
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Summary:Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor 5 disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and/or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time o electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and/or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.
Bibliography:Application Number: AU20160216735