Topical delivery of skin compositions having low pH

Low pH compositions for topical administration to skin are provided. They comprise a buffering agent having a pKa of about 2.8 to about 4.2 and a cosmetically acceptable 5 active ingredient having a pKa within about 1 unit of the pKa of the buffering agent. The composition has a pH of about 3.3 to 4...

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Main Authors Fassih, Ali, Sun, Ying, Parsa, Ramine, Brillouet, Anne-Sophie, Paturi, Jyotsna, Rossetti, Dianne, Garcia, Devin L, Hu, Ya-Ping, Yates, Robert Wayne, Li, Wen-Hwa Ting, Wangari-Talbot, Janet, Dufort, Marisa DeVita
Format Patent
LanguageEnglish
Published 09.02.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Summary:Low pH compositions for topical administration to skin are provided. They comprise a buffering agent having a pKa of about 2.8 to about 4.2 and a cosmetically acceptable 5 active ingredient having a pKa within about 1 unit of the pKa of the buffering agent. The composition has a pH of about 3.3 to 4 and a buffer capacity of at least about 0.15. A method of increasing the topical delivery of a cosmetically acceptable active ingredient having a pKa of about 2.8 to about 4 is also provided.
Bibliography:Application Number: AU20160206278