PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF

The present invention provides a compound of formula I wherein X", R1, and R2 are as defined herein, and compositions thereof. The compounds include and are based on an impurity of methylnaltrexone, a peripheral opioid antagonist.

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Bibliographic Details
Main Authors SHAH, SYED M, ZHU, TIANMIN, MEGATI, SREENIVASULU, LOKHNAUTH, JOHN, OFSLAGER, CHRISTIAN, FABIAN, STEVEN R, RADEBAUGH, GALEN, MELUCCI, CHARLES, PATEL, NIKETA, BAZHINA, NATALIYA, ZHANG, HUYI, SZELIGA, JAN, DONATO, GEORGE JOSEPH
Format Patent
LanguageEnglish
Published 17.03.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a compound of formula I wherein X", R1, and R2 are as defined herein, and compositions thereof. The compounds include and are based on an impurity of methylnaltrexone, a peripheral opioid antagonist.
Bibliography:Application Number: AU20160201221