Amine polymers for use as bile acid sequestrants

• Main Authors: CONNOR, ERIC, MANSKY, PAUL, LEE, ANGELA, GOKA, ELIZABETH, ZHANG, XINNAN, SALAYMEH, FELAH, ZHANG, HONGMIN, QUAKER, GRACE, COPE, MICHAEL JAMES, SHAO, JUN, MU, YONGQI, BERGBREITER, DAVID, LEES, INEZ, MADSEN, DEIDRE, BIYANI, KALPESH, HECKER, SCOTT
• Format: Patent
• Language: English
• Published: 25.02.2016
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome diarrhea (IBS-D), bile acid malabsorption, and like.