RNA interference agents for GST-pi gene modulation

This invention provides compounds, compositions and methods for modulating the expression of human GST-pi using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or...

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Bibliographic Details
Main Authors Ahmadian, Mohammad, Takahashi, Hirokazu, Ying, Wenbin, Harborth, Jens, Zhang, Jun, Terada, Erika, Minomi, Kenjirou
Format Patent
LanguageEnglish
Published 10.08.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This invention provides compounds, compositions and methods for modulating the expression of human GST-pi using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications
Bibliography:Application Number: AU20150369592