Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds

Compositions and compounds having nucleoside phosphoramidites, and methods of making the same are provided. The compounds can also have one or more amino groups that each can be positively charged. The compounds described permit facile attachment of certain neutralizing moieties with positive charge...

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Bibliographic Details
Main Authors Yanachkov, Ivan, Tabatadze, David R
Format Patent
LanguageEnglish
Published 07.05.2020
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:Compositions and compounds having nucleoside phosphoramidites, and methods of making the same are provided. The compounds can also have one or more amino groups that each can be positively charged. The compounds described permit facile attachment of certain neutralizing moieties with positive charges at their terminal ends on the backbones of oligonucleotides. The compounds can be used for the treatment of cancer, autoimmune, genetic and infectious diseases.
Bibliography:Application Number: AU20150350001