Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles

The present invention is directed to pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggre...

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Bibliographic Details
Main Authors Bennacef, Idriss, Greshock, Thomas, Wang, Yaode, Selnick, Harold, Fu, Jianmin, Hostetler, Eric, Li, Jing, Walji, Abbas M, Moore, Keith P, Mulhearn, James, Yang, Kun
Format Patent
LanguageEnglish
Published 22.11.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention is directed to pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer's patients. More specifically, this invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study tau deposits in brain
Bibliography:Application Number: AU20150274843