Calicheamicin derivative-carrier conjugates

CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/ anti...

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Main Authors Robbins, Paul David, Simpson, John McLean, Moran, Justin Keith, Dijoseph, John Francis, Popplewell, Andrew George, Merchant, Nishith, Damle, Nitin Krishnaji, Ruppen, Mark Edward, Rubino, Joseph Thomas, Kunz, Arthur, Jain, Neera, Vidunas, Eugene Joseph
Format Patent
LanguageEnglish
Published 29.06.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/ antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. (10082632 1):GGG
Bibliography:Application Number: AU20150246156