Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use

• Main Authors: XU, JEAN, LI, YING, MUSLEHIDDINOGLU, JALE, BEAUCHAMPS, MARIE GEORGES, YONG, KELVIN HIN-YEONG, HUANG, LIANFENG, FERRETTI, ANTONIO CHRISTIAN, KOTHARE, MOHIT ATUL, BOERSEN, NATHAN ANDREW, ZHOU, NANFEI, NAGY, MARK A, HILGRAF, ROBERT, MAN, HON-WAH, ZOU, DAOZHONG
• Format: Patent
• Language: English
• Published: 11.08.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3- hydroxy-4-methy1cydohexylamino)-pyrimidine-5-carboxamide (Compound I). In another aspect, provided herein are methods for preparing certain compounds, including Compound I as described herein, as well as intermediates useful in such methods. In certain aspects, the solid forms of Compound I are useful for inhibiting a kinase in a cell expressing said kinase, for example JNK1 or JNK2. In another aspect, the solid forms of Compound I are useful for treating or preventing one or more disorders selected from interstitial pulmonary fibrosis, systemic sclerosis, scleroderma, chronic allograft nephropathy, antibody mediated rejection, or lupus.