Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity

The present disclosure provides aromatic-cationic peptides and methods of using the same. The methods comprise the use of the aromatic-cationic peptides in reducing the effects of toxic beta amyloid (Aβ) peptides including blocking the accumulation of extracellular Aβ oligomers, inhibiting Aβ-mediat...

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Bibliographic Details
Main Authors Szeto, Hazel H, Szabo, Paul, Ren, Margarita, Zhao, Brian Yinge, Birk, Alexander V
Format Patent
LanguageEnglish
Published 27.02.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides aromatic-cationic peptides and methods of using the same. The methods comprise the use of the aromatic-cationic peptides in reducing the effects of toxic beta amyloid (Aβ) peptides including blocking the accumulation of extracellular Aβ oligomers, inhibiting Aβ-mediated oxygenase activity, reducing Aβ-induced mitochondrial dysfunction and/or preventing Aβ-induced neuronal apoptosis.
Bibliography:Application Number: AU20140324580