Synthesis of tetracyclines and analogues thereof

H:Ada.1nicnvov.nNRPorbl\DCC\DAR689S12_L DC-17/101lin The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organism...

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Bibliographic Details
Main Authors LERNER, CHRISTIAN D, MYERS, ANDREW G, BRUBACKER, JASON D, SIEGEL, DIONICIO R, CHAREST, MARK G
Format Patent
LanguageEnglish
Published 26.05.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:H:Ada.1nicnvov.nNRPorbl\DCC\DAR689S12_L DC-17/101lin The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analo gs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
Bibliography:Application Number: AU20140250722