Cis-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer

The present invention provides MDM2 inhibitor compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharma...

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Bibliographic Details
Main Authors Yan, Xuelei, Beck, Hilary Plake, Olson, Steven H, Fox, Brian M, Julian, Lisa D, Degraffenreid, Michael R, Roveto, Philip M, Bartberger, Michael D, Sun, Daqing, Gonzalez Lopez De Turiso, Felix, Medina, Julio C, Rew, Yosup, Kayser, Frank
Format Patent
LanguageEnglish
Published 01.03.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides MDM2 inhibitor compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
Bibliography:Application Number: AU20140219075