Aminopyrimidines as Syk inhibitors

AMINOPYRIMIDINES AS SYK INHIBITORS Abstract The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

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Bibliographic Details
Main Authors KATTAR, SOLOMON, CHILDERS, KALEEN KONRAD, ANDRESEN, BRIAN M, KNOWLES, SANDRA LEE, GUAY, DANIEL, ROBICHAUD, JOEL S, O'BOYLE, BRENDAN M, FOURNIER, JEAN-FRANCOIS, SCHELL, ADAM J, ALTMAN, MICHAEL D, MACHACEK, MICHELLE R, ARRINGTON, KENNETH L, FRANCESCO, MARIA EMILIA DI, GAUTHIER, JACQUES YVES, ROMEO, ERIC, OTTE, RYAN D, LIM, JONGWON, COTE, BERNARD, BURCH, JASON, REUTERSHAN, MICHAEL H, DUPONT-GAUDET, KRISTINA, GUERIN, DAVID JOSEPH, NORTHRUP, ALAN B, SIU, TONY, WOO, HYUN CHONG, MADDESS, MATTHEW L, ELLIS, JOHN MICHAEL, BHAT, SATHESH, TROTTER, B. WESLEY, SPENCER, KERRIE B, PETROCCHI, ALESSIA, FISCHER, CHRISTIAN, HAIDLE, ANDREW M, ZHOU, HUA, DONOFRIO, ANTHONY, TAOKA, BRANDON M, GRIMM, JONATHAN, LI, CHAOMIN
Format Patent
LanguageEnglish
Published 30.01.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:AMINOPYRIMIDINES AS SYK INHIBITORS Abstract The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
Bibliography:Application Number: AU20140200138