Treatment of cancer with heterocyclic inhibitors of glutaminase

The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof and the methods of treating or preventing cancer using the compounds of the invention. Other aspects relate to methods of identifying a cancer patient that may benefit from treatment with a glutaminase inhi...

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Main Authors GROSS, MATTHEW I, CHEN, LIJING, STANTON, TIMOTHY FRIEND, BENNETT, MARK K, BROMLEY, SUSAN D, LI, JIM, LAIDIG, GUY, SJOGREN, ERIC BRIAN, GOYAL, BINDU
Format Patent
LanguageEnglish
Published 09.07.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof and the methods of treating or preventing cancer using the compounds of the invention. Other aspects relate to methods of identifying a cancer patient that may benefit from treatment with a glutaminase inhibitor comprising determining the ratio of glutamate to glutamine, the ratio of glutaminase enzyme to glutamine synthetase or glutaminase activity in cancer cells of the patient.
Bibliography:Application Number: AU20130356241