Spliceostatin analogs

The present invention is directed to novel cytotoxic spliceostatin analogs (I) and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.

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Bibliographic Details
Main Authors Eustaquio, Alessandra S, Ratnayake, Anokha Sayani, Yang, Hui Yu, He, Haiyin, Teske, Jesse Alexander, Puthenveetil, Sujiet, Dirico, Kenneth John, Koehn, Frank Erich, Subramanyam, Chakrapani, Green, Michael Eric, He, Min, O'Donnell, Christopher John
Format Patent
LanguageEnglish
Published 30.11.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention is directed to novel cytotoxic spliceostatin analogs (I) and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Bibliography:Application Number: AU20130340449