Liposomal compositions of epoxyketone-based proteasome inhibitors

Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions enhance the therapeutic window of peptide epoxyketone compounds by improving in vivo half-life relative to non-liposomal com...

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Bibliographic Details
Main Authors JONES, JEFFREY JOSEPH, WANG, ZHENGPING, FANG, YING, JIANG, JING, CHU, KATHERINE A, KIRK, CHRISTOPHER JUSTIN, JUMAA, MOUHANNAD, MUCHAMUEL, TONY MARCEL, CHAN, ELENA T
Format Patent
LanguageEnglish
Published 05.02.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions enhance the therapeutic window of peptide epoxyketone compounds by improving in vivo half-life relative to non-liposomal compositions comprising peptide epoxyketone compounds, providing desirable pharmacodynamic profiles, and providing anti¬ tumor activity in a human tumor xenograft model, greater than or equal to non-liposomal compositions comprising peptide epoxyketone compounds. Further, experiments performed in support of the present invention demonstrated improved tolerability of liposomal compositions comprising peptide epoxyketone compounds.
Bibliography:Application Number: AU20130292647