Prolonged inhibition of interleukin-6 mediated signaling

Polypeptides are provided directed against IL-6R at specific dose ranges and dosing schedules that result in a prolonged effect on IL-6 mediated signaling. In particular, the invention provides pharmacologically active agents, compositions, methods and/or dosing schedules that have certain advantage...

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Bibliographic Details
Main Authors Holz, Josefin-Beate, Sargentini-Maier, Maria Laura, Yalkinoglu, Ozkan, De Bruyn, Steven, Rossenu, Stefaan
Format Patent
LanguageEnglish
Published 01.12.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Polypeptides are provided directed against IL-6R at specific dose ranges and dosing schedules that result in a prolonged effect on IL-6 mediated signaling. In particular, the invention provides pharmacologically active agents, compositions, methods and/or dosing schedules that have certain advantages compared to the agents, compositions, methods and/or dosing schedules that are currently used and/or known in the art, including the ability to dose less frequently or to administer lower doses to obtain eq uivalent effects in inhibiting IL-6 mediated signaling.
Bibliography:Application Number: AU20120311443