Novel anti-human NGF antibody

[Problem] To provide: an anti-human NGF antibody which is reduced in the influence on fetuses and the risk of adverse side effects including thrombosis while keeping a high neutralizing activity, and which has excellent safety, or an antigen-binding fragment thereof; and a means for preventing or tr...

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Bibliographic Details
Main Authors Yoshimi, Eiji, Kamohara, Masazumi, Tanaka, Hirotsugu, Koya, Yukari, Takasaki, Jun, Yonezawa, Atsuo
Format Patent
LanguageEnglish
Published 27.04.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:[Problem] To provide: an anti-human NGF antibody which is reduced in the influence on fetuses and the risk of adverse side effects including thrombosis while keeping a high neutralizing activity, and which has excellent safety, or an antigen-binding fragment thereof; and a means for preventing or treating various diseases for which human NGF is involved in the development of a disease state, which utilizes the antibody or an antigen-binding fragment thereof. [Solution] An Fab' fragment of an anti-human NGF antibody, which comprises a heavy-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 6 and a light-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 4.
Bibliography:Application Number: AU20120293161