Production and use of bacterial histamine
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. In particular the present invention relates to a method of selecting a lactic acid bacterial strain for use in the local production of histami...
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
30.01.2014
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Subjects | |
Online Access | Get full text |
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Summary: | A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. In particular the present invention relates to a method of selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, wherein said method comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions. |
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Bibliography: | Application Number: AU20120285657 |