18-membered macrocycles and analogs thereof

The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. 5 In particular, this compound is a...

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Bibliographic Details
Main Authors HWANG, CHAN-KOU, ROMERO, ALEX, SEARS, PAMELA, CHIU, YU-HUNG, BABAKHANI, FARAH, OKUMO, FRANKLIN, SHUE, YOUE-KONG
Format Patent
LanguageEnglish
Published 11.07.2013
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. 5 In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
Bibliography:Application Number: AU20120200784