Bone void fillers

• Main Authors: WILHELM, NICHOLE, ACKER, DEAN M, AKELLA, RAMA, LI, SHULIANG, WEN, HAI BO, GARRETT, IAN ROSS
• Format: Patent
• Language: English
• Published: 28.05.2015
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

A bone void filler composition containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material, and methods of making and using the composition, are described. The bone void filler composition may be in the form of a sponge of any desired shape or in the form of a paste or putty that is used to form a sponge or is obtained from particulated sponge, or a paste or putty that forms after a sponge is rehydrated. A pre-mixed bone void filler composition containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a biologically acceptable carrier component that contains a liquid carrier, and methods of making and using the composition, are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.