Vaccine compositions based on sticholysin encapsulated in liposomes

• Main Authors: MESA PARDILLO, CIRCE, ALVAREZ VALCARCEL, CARLOS MANUEL, PAZOS SANTOS, ISABEL FABIOLA, TEJUCA MARTINEZ, MAYRA, VALLE GARAY, AISEL, FERNANDEZ MOLINA, LUIS ENRIQUE, CANET SANTOS, LIEM, LANIO RUIZ, MARIA ELIANA, LABORDE QUINTANA, RADY JUDITH, LUZARDO LORENZO, MARIA DEL CARMEN, ALONSO BIOSCA, MARIA EUGENIA, CRUZ LEAL, YOELYS
• Format: Patent
• Language: English
• Published: 19.12.2013
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to the field of biotechnology as applied to human health. The invention describes a vaccine vehicle in which toxins from eukaryotic organisms are encapsulated in liposomes with multiple lipid layers, obtained by means of the process of dehydration/rehydration, the lipid composition of which is dipalmitoylphosphatidylcholine:cholesterol in a molar ratio of 1:1, which are designed for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The compositions described allow modulation of the specific CTL immune response to one or more antigens co-encapsulated in the liposomes that contain the toxin. The vaccine vehicle of the present invention presents advantages as compared with others described in the prior art owing to the robust and functional nature of the immune response induced and also the immunomodulating properties thereof.