Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor
-THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR Abstract The invention generally relates to use of 8-fluoro-2-{4-[(methylamino)methyl]pheny)}-1, 5 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by Formula (1) as a chemosensitizer that enhances the efficacy o...
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Format | Patent |
Language | English |
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12.01.2012
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Abstract | -THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR Abstract The invention generally relates to use of 8-fluoro-2-{4-[(methylamino)methyl]pheny)}-1, 5 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by Formula (1) as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. The invention also relates to pharmaceutical combinations of 8-fluoro-2-{4-[(methylamino)methylpheny)}-1, 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of 10 using such combinations to treat subjects suffering from diseases such as cancer. |
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AbstractList | -THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR Abstract The invention generally relates to use of 8-fluoro-2-{4-[(methylamino)methyl]pheny)}-1, 5 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by Formula (1) as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. The invention also relates to pharmaceutical combinations of 8-fluoro-2-{4-[(methylamino)methylpheny)}-1, 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of 10 using such combinations to treat subjects suffering from diseases such as cancer. |
Author | DEWJI, MOHAMED RAZA JONES, CHRISTOPHER KAUFMAN, RHONDA THOMAS, HUW DAVID WILLIAMS, KAYE JANINE REICH, STEVEN DAVID CALVERT, ALAN HILARY STRATFORD, IAN J STEINFELDT, HEIDI MARIE NEWELL, DAVID RICHARD BORITZKI, THEODORE JAMES HOSTOMSKY, ZDENEK PLUMMER, ELIZABETH RUTH KLAMERUS, KAREN J CURTIN, NICOLA JANE |
Author_xml | – fullname: STEINFELDT, HEIDI MARIE – fullname: CURTIN, NICOLA JANE – fullname: JONES, CHRISTOPHER – fullname: THOMAS, HUW DAVID – fullname: DEWJI, MOHAMED RAZA – fullname: CALVERT, ALAN HILARY – fullname: REICH, STEVEN DAVID – fullname: NEWELL, DAVID RICHARD – fullname: PLUMMER, ELIZABETH RUTH – fullname: BORITZKI, THEODORE JAMES – fullname: KAUFMAN, RHONDA – fullname: HOSTOMSKY, ZDENEK – fullname: KLAMERUS, KAREN J – fullname: STRATFORD, IAN J – fullname: WILLIAMS, KAYE JANINE |
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Title | Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor |
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