Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor

-THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR Abstract The invention generally relates to use of 8-fluoro-2-{4-[(methylamino)methyl]pheny)}-1, 5 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by Formula (1) as a chemosensitizer that enhances the efficacy o...

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Main Authors STEINFELDT, HEIDI MARIE, CURTIN, NICOLA JANE, JONES, CHRISTOPHER, THOMAS, HUW DAVID, DEWJI, MOHAMED RAZA, CALVERT, ALAN HILARY, REICH, STEVEN DAVID, NEWELL, DAVID RICHARD, PLUMMER, ELIZABETH RUTH, BORITZKI, THEODORE JAMES, KAUFMAN, RHONDA, HOSTOMSKY, ZDENEK, KLAMERUS, KAREN J, STRATFORD, IAN J, WILLIAMS, KAYE JANINE
Format Patent
LanguageEnglish
Published 12.01.2012
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:-THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR Abstract The invention generally relates to use of 8-fluoro-2-{4-[(methylamino)methyl]pheny)}-1, 5 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by Formula (1) as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. The invention also relates to pharmaceutical combinations of 8-fluoro-2-{4-[(methylamino)methylpheny)}-1, 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of 10 using such combinations to treat subjects suffering from diseases such as cancer.
Bibliography:Application Number: AU20110253816