Amino -dihydrooxazine and amino - dihydrothiazine spiro compounds as Beta - secretase modulators and their medical use

• Main Authors: ZHONG, WENGE, WHITE, RYAN, MINATTI, ANA ELENA, PARAS, NICK A, LOPEZ, PATRICIA, MARX, ISAAC, QIAN, WENYUAN, CHENG, YUAN, CHEN, JIAN J, YANG, BRYANT, JUDD, TED, POWERS, TIMOTHY, WEISS, MATTHEW, EPSTEIN, OLEG, DINEEN, THOMAS, POTASHMAN, MICHELE, LOW, JONATHAN
• Format: Patent
• Language: English
• Published: 20.09.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I): wherein A, A, A, A, A, A, R, R, X, Y and Z of Formula (I) are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula (I), intermediates and processes useful for the preparation of compounds of Formula (I).