Compositions and methods for manipulating levels of antigen-specific antibodies in a mammal

The invention provides compositions and methods for increasing the levels of an autoantigen-specific IgM antibody in a mammal and, thus, decreasing the levels of a circulating autoantigen in a mammal. Using these autoantigen-specific IgM antibodies, the invention 5 provides compositions and methods...

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Bibliographic Details
Main Author BARABAS, ARPAD Z
Format Patent
LanguageEnglish
Published 15.12.2011
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides compositions and methods for increasing the levels of an autoantigen-specific IgM antibody in a mammal and, thus, decreasing the levels of a circulating autoantigen in a mammal. Using these autoantigen-specific IgM antibodies, the invention 5 provides compositions and methods for ameliorating an autoimmune disease in a mammal. In one aspect, the invention provides compositions and methods for increasing the levels of an antigen-specific IgG antibody in a mammal and, thus, decreasing the levels of a circulating antigen in a mammal. Using these antigen-specific IgG antibodies, the invention provides compositions and methods for ameliorating a disease or condition in a mammal, e.g., a cancer or 10 a foreign antigen, such as a pathogen.
Bibliography:Application Number: AU20110218660